Di iso propyl ether

To produce diisopropyl ether, propylene is first hydrated with water over a supported acidic catalyst to produce IPA iso propanol. This is then reacted further with either propylene, or additional IPA, to form DIPE with reaction conditions controlled to promote the etherification with propylene. Diisopropyl ether has a specific gravity of 0. It should therefore be stored in a cool, dry, well-ventilated area that is free from the risk of ignition.

For transportation purposes, Diisopropyl ether is classified as packing group II and hazard class 3 and should be labelled as highly flammable and harmful. Diisopropyl ether can be used in a wide variety of applications. Its most common use is as a solvent as oil-based solutions dissolve in it.

This makes it the ideal base for many paints, waxes, dyes and resins. It is also used as a solvent in paint thinners and stain removers. Description of substance: Colorless liquid with a sharp, sweet, ether-like odor.

Other animal data: It has been reported that animals survived a 4-hour exposure to 8, ppm [UCC ]. Human data: Volunteers exposed to ppm for 5 minutes reported irritation of the eyes and nose [Silverman et al. Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [UCC ], a value of about 3, ppm would have been appropriate for isopropyl ether.

However, the revised IDLH for isopropyl ether is 1, ppm based strictly on safety considerations i. The physiological response to isopropyl ether and to a mixture of isopropyl ether and gasoline. J Ind Hyg Toxicol 21 Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data.

Diisopropyl ether DIPE is a widely used solvent but the possibility of using it in the pharmaceutical manufacture is uncertain because the ICH Q3C guideline includes it in the group of solvents for which "no adequate toxicological data on which to base a Permitted Daily Exposure PDE was found".

We performed a risk assessment of DIPE based on available toxicological data, after carefully assessing their reliability using the Klimisch score approach.